Laboratory of Evolutionary Anthropology (Nakayama Unit), The University of Tokyo
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Boonvisut S, Yoshida K, Nakayama K, Watanabe K, Miyashita H, Iwamoto S.  Identification of deleterious rare variants in MTTP, PNPLA3,  and TM6SF2 in Japanese males and association studies with NAFLD. Lipids Health Dis. 2017. 16:183

Nakayama K*, Ohashi J, Watanabe K, Munkhtulga L, Iwamoto S. Evidence for Very Recent Positive Selection in Mongolians. Mol Biol Evol.  2017. 34:1936-1946
Nakayama K*, Iwamoto S. An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues J Phyiol Anthropol. 36:16 2017
Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Kamo Y, Tada K, Ishizuka S, Niwa T, Iwamoto S, Shimizu H*. Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotech Biochem. 2017.  81:1120-1124
Watanabe K*, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S. ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. Biochem Biophys Res Commun. 2016 477:712-6.
Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T*. Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly. Prostaglandins Leukot Essent Fatty Acids. 2016 105:9-14.
Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M, Kagawa Y, Iwamoto S*. Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups. Lipids Health Dis. 2016 15:8.
Yang Z, Matsumoto A, Nakayama K, Jimbo EF, Kojima K, Nagata K, Iwamoto S, Yamagata T*. Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients. Brain Dev. 2016 38:91-9.
Kagawa Y, Nishijima C, Nakayama K, Iwamoto S, Tanaka A, Kawabata T. Nutrigenetics of Japanese Vegetarians with Polymorphism in the Fatty Acid Desaturase. J Nutr Food Sci. 2016 6:498.
 Makishima S, Boonvisut S, Ishizuka Y, Watanabe K, Nakayama K, Iwamoto S*. Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression. J Lipid Res. 2015 56:1145-52.
Iwamoto S*, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K. The role of TRIB1 in lipid metabolism; from genetics to pathways. Biochem Soc Trans. 2015 43:1063-1068.
Nakayama K*, Miyashita H, Iwamoto S. Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults. J Physiol Anthropol. 2014 33:38.
Nakayama K*, Watanabe K, Boonvisut S, Makishima S, Miyashita H, Iwamoto S. Common variants of GIP are associated with visceral fat accumulation in Japanese adults. Am J Physiol Gastrointest Liver Physiol. 2014 307: G1108-14.
Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S*; Jichi Medical University Promotion Team of Large-Scale Human Genome Bank for All over Japan. TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol. 2014 52:145-58.
Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J. A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. Int J Obes (Lond). 2013 37:1204-10.
Nakayama K*, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S. Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. Hum Genet. 2013 132:201-17.
Nakayama K*, Miyashita H, Yanagisawa Y, Iwamoto S. Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults. PLoS One. 2013 8: e74720.
 Panichareon B†, Nakayama K†, Iwamoto S, Thurakitwannakarn W, Sukhumsirichart W*. Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population. Behav Brain Funct. 2012 8:27. †Equally contributed
Panichareon B†, Nakayama K†, Thurakitwannakarn W, Iwamoto S, Sukhumsirichart W*. OPCML gene as a schizophrenia susceptibility locus in Thai population. J Mol Neurosci. 2012 46:373-7. †Equally contributed
Nakayama K*, Yanagisawa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S. High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia. J Hum Genet. 2011 56:828-33.
Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S*; Jichi Medical University Promotion Team of a Large-scale Human Genome Bank for All over Japan. A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet. 2010 127:685-90.
Nakayama K, Shotake T, Takeneka O, Ishida T*. Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques. J Mammal Evol. 2010 17: 211-4.
Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S*. Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI. Obesity (Silver Spring). 2010 18:1006-14.
Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S*; Jichi Community Genetics Team (JCOG). Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009 46:370-4.
Nakayama K, Shotake T, Takeneka O, Ishida T*. Variation of the melanocortin 1 receptor gene in the macaques. Am J Primatol. 2008 Aug;70(8):778-85.
Yanagisawa Y, Munkhtulga L, Nakayama K, Iwamoto S, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Kawabata T, Kaneko Y, Watanabe S, Sakuma M, Komatsu F, Hasegawa K, Kagawa Y. Diversity in genes responsible for lifestyle-related diseases in Asia-Pacific region. Asia Pac J Public Health. 2008 20 S257-61.
Nakayama K*, Lkhagvasuren M, Yanagisawa Y, Utsumi N, Kumada M, Gotoh T, Iwamoto S, Kagawa Y. Comparative study of polymorphisms on genes associated with lifestyle related diseases in Asian and Pacific populations. Asia Pac J Public Health. 2008 20: S173-9.
Higasa S, Tsujimura M, Hiraoka M, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Genetic polymorphisms of xenobiotic enzymes affect human vitamin C excretion. Asia Pac J Public Health. 2008 20: S70-9.
Tsujimura M, Higasa S, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading. J Nutr Sci Vitaminol (Tokyo). 2008 54:315-20.
Higasa S, Tsujimura M, Hiraoka M, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism. Biochem Biophys Res Commun. 2007 364:708-13.
Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S*. Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia. Hum Genet. 2007 120:879-88.
Nakayama K, Ishida T*. Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes. Genome Res. 2006 16:485-90.
Nakayama K, Soemantri A, Jin F, Dashnyam B, Ohtsuka R, Duanchang P, Isa MN, Settheetham-Ishida W, Harihara S, Ishida T*. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet. 2006 Apr;119(3):322-30.
Nakayama K, Fukamachi S, Kimura H, Koda Y, Soemantri A, Ishida T*. Distinctive distribution of AIM1 polymorphism among major human populations with different skin color. J Hum Genet. 2002 47:92-4.

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