2016年以前の業績

 

＜原著論文＞（査読有）* Corresponding author

 

1.           Watanabe K*, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S. ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. Biochem Biophys Res Commun. 2016 477:712-6.

 

2.           Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T*. Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly. Prostaglandins Leukot Essent Fatty Acids. 2016 105:9-14.

 

3.           Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M, Kagawa Y, Iwamoto S*. Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups. Lipids Health Dis. 2016 15:8.

 

4.           Yang Z, Matsumoto A, Nakayama K, Jimbo EF, Kojima K, Nagata K, Iwamoto S, Yamagata T*. Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients. Brain Dev. 2016 38:91-9.

 

5.           Kagawa Y, Nishijima C, Nakayama K, Iwamoto S, Tanaka A, Kawabata T. Nutrigenetics of Japanese Vegetarians with Polymorphism in the Fatty Acid Desaturase. J Nutr Food Sci. 2016 6:498.

 

6.           Makishima S, Boonvisut S, Ishizuka Y, Watanabe K, Nakayama K, Iwamoto S*. Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression. J Lipid Res. 2015 56:1145-52.

 

7.           Iwamoto S*, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K. The role of TRIB1 in lipid metabolism; from genetics to pathways. Biochem Soc Trans. 43:1063-1068. 2015

 

8.           Nakayama K*, Miyashita H, Iwamoto S. Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults. J Physiol Anthropol. 2014 33:38.

 

9.           Nakayama K*, Watanabe K, Boonvisut S, Makishima S, Miyashita H, Iwamoto S. Common variants of GIP are associated with visceral fat accumulation in Japanese adults. Am J Physiol Gastrointest Liver Physiol. 2014 307: G1108-14.

 

10.        中山一大*、宮下洋、岩本禎彦 健診集団情報を用いたMLXIPL Gln241His多型の適応的意義の検討 日本生理人類学会誌 19:63-67.

 

11.        Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S*; Jichi Medical University Promotion Team of Large-Scale Human Genome Bank for All over Japan. TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol. 2014 52:145-58.

 

12.        Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J. A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. Int J Obes (Lond). 2013 37:1204-10.

 

13.        Nakayama K*, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S. Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. Hum Genet. 2013 132:201-17.

 

14.        Nakayama K*, Miyashita H, Yanagisawa Y, Iwamoto S. Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults. PLoS One. 2013 8: e74720.

 

15.        Panichareon B†, Nakayama K†, Iwamoto S, Thurakitwannakarn W, Sukhumsirichart W*. Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population. Behav Brain Funct. 2012 8:27. †Equally contributed

 

16.        Panichareon B†, Nakayama K†, Thurakitwannakarn W, Iwamoto S, Sukhumsirichart W*. OPCML gene as a schizophrenia susceptibility locus in Thai population. J Mol Neurosci. 2012 46:373-7. †Equally contributed

 

17.        Nakayama K*, Yanagisawa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S. High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia. J Hum Genet. 2011 56:828-33.

 

18.        Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S*; Jichi Medical University Promotion Team of a Large-scale Human Genome Bank for All over Japan. A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet. 2010 127:685-90.

 

19.        Nakayama K, Shotake T, Takeneka O, Ishida T*. Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques. J Mammal Evol. 2010 17: 211-4.

 

20.        Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S*. Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI. Obesity (Silver Spring). 2010 18:1006-14.

 

21.        Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S*; Jichi Community Genetics Team (JCOG). Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009 46:370-4.

 

22.        Nakayama K, Shotake T, Takeneka O, Ishida T*. Variation of the melanocortin 1 receptor gene in the macaques. Am J Primatol. 2008 Aug;70(8):778-85.

 

23.        Yanagisawa Y, Munkhtulga L, Nakayama K, Iwamoto S, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Kawabata T, Kaneko Y, Watanabe S, Sakuma M, Komatsu F, Hasegawa K, Kagawa Y. Diversity in genes responsible for lifestyle-related diseases in Asia-Pacific region. Asia Pac J Public Health. 2008 20 S257-61.

 

24.        Nakayama K*, Lkhagvasuren M, Yanagisawa Y, Utsumi N, Kumada M, Gotoh T, Iwamoto S, Kagawa Y. Comparative study of polymorphisms on genes associated with lifestyle related diseases in Asian and Pacific populations. Asia Pac J Public Health. 2008 20: S173-9.

 

25.        Higasa S, Tsujimura M, Hiraoka M, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Genetic polymorphisms of xenobiotic enzymes affect human vitamin C excretion. Asia Pac J Public Health. 2008 20: S70-9.

 

26.        Tsujimura M, Higasa S, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading. J Nutr Sci Vitaminol (Tokyo). 2008 54:315-20.

 

27.        Higasa S, Tsujimura M, Hiraoka M, Nakayama K, Yanagisawa Y, Iwamoto S, Kagawa Y*. Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism. Biochem Biophys Res Commun. 2007 364:708-13.

 

28.        Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S*. Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia. Hum Genet. 2007 120:879-88.

 

29.        Nakayama K, Ishida T*. Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes. Genome Res. 2006 16:485-90.

 

30.        Nakayama K, Soemantri A, Jin F, Dashnyam B, Ohtsuka R, Duanchang P, Isa MN, Settheetham-Ishida W, Harihara S, Ishida T*. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet. 2006 Apr;119(3):322-30.

 

31.        Nakayama K, Fukamachi S, Kimura H, Koda Y, Soemantri A, Ishida T*. Distinctive distribution of AIM1 polymorphism among major human populations with different skin color. J Hum Genet. 2002 47:92-4.

 

 

 

＜総説＞　* Corresponding author

 

1.         中山一大^*「生物基礎」と「生物」で理解するヒトの遺伝と進化. Anthropol Sci (Japanese Series). 2015. 123: 67-73.

 

2.         中山一大* ゲノム多様性情報から集団を科学する 日本生理人類学会誌. 2014. 19:253-67.

 

3.         中山一大* ゲノム人類学の最先端 vol.8 内臓脂肪関連遺伝子多型の進化 医学のあゆみ. 2014. 249:642-4.

 

4.         中山一大* 遺伝・ゲノム学 内臓脂肪蓄積に関連する新規遺伝子TRIB2の同定とその進化パターンの解析 医学のあゆみ. 2013. 246:977-8.

 

5.         中山一大*【ゲノム人類学入門】「出アフリカ」以後の人類拡散と疾患リスク遺伝子―もう一つの進化医学【Part3:進化の視点から考える疾患変異】内臓脂肪蓄積に関連する遺伝子とその進化 生物の科学 遺伝. 2013. 67: 339-45.

 

6.         香川 靖雄, 日笠 志津, 辻村 卓, 影山 光代, 百合本 真弓, 金胎 芳子, 小島 早貴, 石井 由香, 柳沢 佳子, 中山 一大, 岩本 禎彦, 平岡 真実. ビタミン関連酵素の多型とテーラーメイド栄養. ビタミン. 2008. 82: 165-72.

 

 

 

＜その他＞

 

1.       中山一大, 市石博士（編・著）日本人類学会教育普及委員会（監）つい誰かに教えたくなる人類学63の大疑問　講談社　2015年11月

 

2.       自然史学会連合 (部分執筆) 理科好きな子に育つふしぎのお話365: 見てみよう、やってみよう、さわってみよう 体験型読み聞かせブック　　誠文堂新光社 p188, 2015年02月

 

3.       西島千陽, 仲本桂子, 中山一大, 廣渡祐史, 田中明, 岩本禎彦, 川端輝江, 香川靖雄 日本人菜食主義者における脂肪酸不飽和化酵素遺伝子の単一塩基多型の血中脂質プロファイルに及ぼす影響  女子栄養大学栄養科学研究所年報. 2013年 19: 94-5.

 

4.       中山一大, 柳沢佳子, 岩本禎彦, 宮下洋, 田原康玄, 恩田智彦, 片嶋充弘, 岡田浩一, 福嶋省吾, 香川靖雄. 内臓脂肪ゲノムバンクの構築と新規内臓脂肪関連遺伝子の同定. DNA多型. 2013. 21: 245-9.

 

5.       石塚裕美, 中山一大,小川歩美, 柳沢佳子, 後藤貴也, 岩本禎彦, 宮下洋. 高脂血症感受性遺伝子TRIB1は高血圧とも関連する. DNA多型 2011. 19:271-4.

 

6.       Panichareon B, Sukhumsirichart W, Nakayama K, Iwamoto S, Thurakitwannakarn W, Kagawa Y. Association study of polymorphisms in CTXN3 gene with schizophrenia in Thai population. DNA多型. 2011. 19:267-70.

 

7.       中山一大, 柳沢佳子,後藤貴也, 山中一央, 小川歩美, 岩本禎彦, ムンフトルガ・ルハグワスレン, 神田芳郎, 石田貴文, 香川靖雄. 脂質代謝に関わる転写因子MLXIPLの遺伝的多様性とその人類生物学的意義. DNA多型. 2010. 18:237-41.

 

8.       小川歩美, 中山一大, 柳沢佳子, 後藤貴也, 山中一央, 岩本禎彦, 宮下洋. 日本人内臓脂肪ゲノムバンクを用いた血清脂質関連遺伝子多型の検証. DNA多型. 2010. 18：246－9.

 

9.       中山一大, ムンフトルガ・ルハグワスレン,後藤貴也,宇津見七海, 熊田真樹, 岩本禎彦 APPL1遺伝子多型と2型糖尿病・肥満の関連解析研究. DNA多型. 2007. 15: 323-6.

 

10.    兵頭 昌雄, 大岩 忠彦, 岩澤 宏哲, 清水 英寿, 中山 一大, 藤江 康光, 堀越 哲郎　メダカ18S rRNA遺伝子のPCRによる増幅　東海大学紀要 開発工学部 1999. 9：213-22.

 

 

 

＜国際学会招待講演＞

 

1.       Nakayama K. Identification of Genetic variants for Visceral Fat Accumulation in Japanese. The 12th International Congress of Physiological Anthropology (Invited). Chiba, Japan, 29 October 2015

 

2.       Nakayama K. Genetics of fat distribution and metabolism: Perspectives from human evolution.  International Symposium on Human Adaptation to Environment and Whole-body Coordination (Invited). Kobe, Japan, 15 March 2015